Environmental Carcinogenesis: Contributions of Basic Research

Contributions of basic research to clinical medicine.

BRCA1 in hormonal carcinogenesis: basic and clinical research.

The breast and ovarian cancer susceptibility gene-1 (BRCA1) located on chromosome 17q21 encodes a tumor suppressor gene that functions, in part, as a caretaker gene in preserving chromosomal stability. The observation that most BRCA1 mutant breast cancers are hormone receptor negative has led some to question whether hormonal factors contribute to the etiology of BRCA1-mutant breast cancers. Ne...

European Community research on environmental mutagenesis and carcinogenesis.

Within the 12 Member States of the European Community (EC), environmental policy is now formulated primarily at Community level. As a result, the EC has important regulatory responsibilities for the protection of workers, consumers, and the general public from risks that may arise from environmental chemicals, foremost among them potential carcinogens and mutagens. An important part of EC envir...

Environmental and chemical carcinogenesis.

People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. It has been estimated that exposure to...

Environmental carcinogenesis and cancers.

I. T H E N A T U R E AND SCOPE OF E N V I R O N M E N T A L CANCER HAZARDS Almost ~00 years have passed since the first environmental carcinogen, coal soot, was recognized as the cause of cancer of the human skin. The environmental carcinogenic spectrum composed of accepted, suspected, and potentially carcinogenic agents present in the natural and artificial human environment has grown consider...